*--* 03-16-92 - 12:26:53 *--* 4 ------------------------------------------------------------------------ Excerpts from : _Smart Drugs and Nutrients_ by Ward Dean MD & John Morgenthaler B&J Publications. PO Box 483, Santa Cruz, CA 95061-0483 ISBN 0-9627418-9-2 ---- DMAE ---- DMAE, or dimethylaminoethanol, is normally present in small amounts in our brains. DMAE is known for its remarkable brain-enhancement effects. It is a naturally occurring nutrient found in seafood such as anchovies and sardines. Perhaps this explains why fish has often been called brain food. DMAE elevates mood, improves memory and learning, increases intelligence, extends life span of laboratory animals (Hochschild, 1978), and increases physical energy. It is used by many people for its mild, safe stimulant effect and yet DMAE also makes it easier for most people to get to sleep. Many people report less fatigue in the day and sounder sleep at night as well More           as needing less sleep when taking DMAE. The stimulant effect of DMAE is significantly different from the stimulation produced by coffee, amphetamines, or other stimulant drugs. DMAE does not have a drug-like quick up and quick come-down. People who take DMAE have reported that after three to four weeks, they feel a mild stimulation continually, without side effects. Also, when DMAE is discontinued, no depression or let-down occurs. Riker laboratories developed a prescription drug called Deaner (sometimes called Deanol). This substance is the p-acetamidobenzoate salt of DMAE and has very similar effects. Riker marketed their DMAE-like product for learning problems, under-achievement, shortened attention span, hyperactivity, reading and speech difficulties, impaired motor coordination, and behavioral problems in children. DMAE works by accellerating the brain's synthesis of the neurotransmitter acetylcholine, which in turn plays a key role in maximizing mental ability as well as in preventing loss of memory in aging adults. Precautions: Overdosage can produce insomnia, dull headaches, or tenseness in muscles especially those of the jaws, neck and legs. These side effects More           disappear if the dosage is lowered slightly. No serious adverse effects have ever been reported with DMAE. Patients with certain types of epilepsy should be closely monitored by a physician. DMAE should not be used by people who are manic depressive because it can deepen the depressive phase. Dosage: DMAE is used initially at low dosages with a gradual build up to 500mg or 1000mg per day. In some cases lower dosages can result in a good response. DMAE can take as long as three weeks to take effect. Sources: DMAE is considered a nutritional supplement and can be found at health food or drug stores. It comes in bulk powder form, capsules, or liquid. Liquid DMAE may spoil if left open or if stored at high temperatures. Keep it tightly sealed in the refrigerator. For sources of DMAE see appendix A. Other names include: Acumen, Atrol, Bimanol, Cervoxan, Deaner, Diforene, Dimethaen, dimethylaminoethanol, Elevan, Pabenol, Paxanol, Risatarun, Tonibral, and Varesal. References: ANDERSON K; ANDERSON L _Orphan Drugs_ Los Angeles, CA: The Body Press, 1987 p 69 More           CEDER; G et al. "Effects of 2-Dimethylaminoethanol (Deanol) on the Metabolism of Choline in Plasma." Journal of Neurochemistry. 1978. Vol30 pp 1293-1296 HOCHSCHILD R. "Effect of Dimethylaminoethyl p-Chlorophenoxy-acetate on the Life Span of Male Swiss Webster Albino Mice." Experimental Gerontology. 1973 Vol8 pp 177-183 HONEGGER C; HONEGGER R. "Occurrence and Quantitative Determination of 2-Dimethylaminoethanol in Animal Tissue Extracts." Nature. 1959 Vol.184 pp 550-552 MURPHREE HB; et al. "The Stimulant Effect of 2-Dimethylaminoethanol (Deanol) in Human Volunteer Subjects." Clinincal Pharmacology and Therapeutics. 1960 Vol.1 pp 303-310 OETTINGER L. "The use of Deanol in the Treatment of Disorders of Behavior in Children." The Journal of Pediatrics. 1958 Vol.3 pp 671-675 More           OSVALDO R. "2-Dimethylaminoethanol (Deanol): A Brief Review of Its Clinical Efficacy and Postulated Mechanism of Action." Current Therapeutic Research. 1974 Vol.16 No.11 pp 1238-1242 PEARSON D; SHAW S. _Life Extension: A Practical Scientific Approach._ New York: Warner Books 1982 PELTON R; PELTON TC. _Mind Food and Smart Pills_ New York: Doubleday 1989 PFEIFFER CC. "Parasympathetic Neurohumors. Possible precursors and Effect on Behavior." International Review of Neurobiology. 1959 pp 195-244 PFIEFFER CC; et al. "Stimulant Effect of 2-Dimethyl-1-aminoethanol: Possible Precursor of Brain Acetylcholine." Science. 1957 Vol.126 pp 610-611 ZUCKERMAN B; BARRETT K. More           "Effects of PCA and DMAE on the Nematode Caenorhabditis Briggsae." Experimental Aging Research. 1978, 4(2) pp 133-139 Appendix A: SOURCES [lists Source Naturals at (800)777-5677 as a supplier for DMAE.] ------------------------------------------------------------------------ The Guild BBS [FTS] (310)641/6909 (1:5150/20) Enter item#, Scan, Quit, ?=Menu DrugInfo : YY